LP-533401

LP-533401 is an inhibitor of tryptophan 5-hydroxylase 1 (Tph1) that blocks the biosynthesis of gut-derived serotonin, completely inhibiting serotonin production in Tph1-expressing cells at a dose of 1 µM. It prevents the development of and fully rescues, in a dose-dependent manner, osteoporosis in ovariectomized and aged mice. LP-533401 has also been used to elucidate the role of gut-derived serotonin in pulmonary hypertension and leukemia in mice.Formal Name: 4-[2-amino-6-[2,2,2-trifluoro-1-(3'-fluoro[1,1'-biphenyl]-4-yl)ethoxy]-4-pyrimidinyl]-L-phenylalanine. CAS Number: 945976-43-2. Molecular Formula: C27H22F4N4O3. Formula Weight: 526.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml, DMSO: 5 mg/ml. lambdamax: 246 nm. SMILES: NC1=NC(C2=CC=C(C[C@H](N)C(O)=O)C=C2)=CC(OC(C(F)(F)F)C3=CC=C(C4=CC(F)=CC=C4)C=C3)=N1. InChi Code: InChI=1S/C27H22F4N4O3/c28-20-3-1-2-19(13-20)16-8-10-18(11-9-16)24(27(29,30)31)38-23-14-22(34-26(33)35-23)17-6-4-15(5-7-17)12-21(32)25(36)37/h1-11,13-14,21,24H,12,32H2,(H,36,37)(H2,33,34,35). InChi Key: JZWUKILTKYJLCN-UHFFFAOYSA-N.