Losartan-d4

Losartan-d4 is intended for use as an internal standard for the quantification of losartan (potassium salt) (Cay-10006594) by GC- or LC-MS. Losartan is an antagonist of the angiotensin (AT) II receptor subtype AT1 with a Ki value of 5-20 nM. It has an attenuating effect on vein graft atherosclerosis in rabbits and effectively reduces arterial blood pressure in rats. Formulations containing losartan have been used to control hypertension while protecting renal function.Formal Name: 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl-2,3,5,6-d4]methyl]-1H-imidazole-5-methanol. CAS Number: 1030937-27-9. Molecular Formula: C22H19ClD4N6O. Formula Weight: 426.9. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Ethanol: 100 mM. SMILES: [H]N1N=NN=C1C2=CC=CC=C2C3=C([2H])C([2H])=C(CN4C(CO)=C(Cl)N=C4CCCC)C([2H])=C3[2H]. InChi Code: InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)/i9D,10D,11D,12D. InChi Key: PSIFNNKUMBGKDQ-IRYCTXJYSA-N.