L189

L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 µM, respectively). It blocks DNA binding (Ki = 5 µM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation. L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.Formal Name: 6-amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone. CAS Number: 64232-83-3. Molecular Formula: C11H10N4OS. Formula Weight: 246.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 222, 294, 360, 378 nm. SMILES: NC(N1)=C(/N=C/C2=CC=CC=C2)C(NC1=S)=O. InChi Code: InChI=1S/C11H10N4OS/c12-9-8(10(16)15-11(17)14-9)13-6-7-4-2-1-3-5-7/h1-6H,(H4,12,14,15,16,17)/b13-6+. InChi Key: SAKOXVNKDMWWLF-AWNIVKPZSA-N.