25 products were found matching "K10777"!

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SCR130
SCR130

Item number: Cay37779-1

SCR130 is an inhibitor of non-homologous end joining (NHEJ) and a derivative of the DNA ligase IV inhibitor SCR7 (Cay-18015). It selectively inhibits DNA ligase IV- over ligase I- or ligase III-mediated end-joining in cell-free assays when used at a concentration of 200 µM. SCR130 is cytotoxic to NALM6 and Reh...
Keywords: 2,4-bis(4-chlorophenyl)-8-thioxo-1,7,9-triazaspiro[4.5]dec-1-ene-6,10-dione
Application: NHEJ (non-homologous end joining) inhibitor
CAS 2377858-38-1
MW: 418.3 D
From 35.00€ *
Review
SCR7
SCR7

Item number: Cay18015-5

DNA ligase IV seals double-strand breaks during the process of nonhomologous end-joining in DNA repair. Inhibiting this function in cancer cells is one strategy to prevent deleterious cell growth. SCR7 is a small molecule inhibitor of DNA ligase IV that prevents nonhomologous end-joining by interfering with ligase...
Keywords: 2,3-dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone
Application: DNA ligase IV inhibitor
CAS 1533426-72-0
MW: 334.4 D
From 43.00€ *
Review
LIG4 BRCT domains (human, recombinant)
LIG4 BRCT domains (human, recombinant)

Item number: Cay14169-100

DNA Ligase 4 (LIG4) is a large protein belonging to the ATP-dependent DNA ligase family. LIG4 contains two BRCA1 C-terminal (BRCT) domains. BRCT domains are modular units of ~100 amino acids that fold independently and recognize linear phosphoserine or phosphothreonine regions to mediate protein-protein and...
Keywords: LIG4, DNA ligase 4, DNA ligase 4, DNA ligase IV, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4,...
Application: Binding assays
Expressed in: E.coli
MW: 57,6 kD
642.00€ *
Review
Anti-LIG4
Anti-LIG4

Item number: ARG55278.100

Protein function: Efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and...
Keywords: Anti-LIG4, EC=6.5.1.1, Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4
Application: WB
Host: Rabbit
Species reactivity: human
624.00€ *
Review
L189
L189

Item number: Cay18374-5

L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 µM, respectively). It blocks DNA binding (Ki = 5 µM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation. L189 preferentially inhibits the interaction of the ligase with damaged DNA,...
Keywords: 6-amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone
Application: DNA ligase I, III, IV inhibitor
CAS 64232-83-3
MW: 246.3 D
From 115.00€ *
Review
Anti-LIG4
Anti-LIG4

Item number: E-AB-18863.120

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex...
Keywords: Anti-LIG4, Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4, LIG4 Polyclonal Antibody
Application: IHC, ELISA
Host: Rabbit
Species reactivity: human, mouse
From 71.00€ *
Review
Anti-LIG4
Anti-LIG4

Item number: E-AB-52776.120

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex...
Keywords: Anti-LIG4, Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4, LIG4 Polyclonal Antibody
Application: IHC, ELISA
Host: Rabbit
Species reactivity: human, mouse
From 71.00€ *
Review
Anti-LIG4
Anti-LIG4

Item number: E-AB-67123.120

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex...
Keywords: Anti-LIG4, Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4, LIG4 Polyclonal Antibody
Application: IF
Host: Rabbit
Species reactivity: human
From 198.00€ *
Review
Anti-DNA Ligase IV
Anti-DNA Ligase IV

Item number: G-CAB11432.100

Protein function: DNA ligase involved in DNA non-homologous end joining (NHEJ), required for double-strand break (DSB) repair and V(D)J recombination (PubMed:8798671, PubMed:9242410, PubMed:9809069, PubMed:12517771, PubMed:17290226). Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing...
Keywords: Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4, DNA Ligase IV Rabbit mAb
Application: WB
Host: Rabbit
Species reactivity: human
From 352.00€ *
Review
Anti-LIG4
Anti-LIG4

Item number: G-CAB1743.100

Application: IHC, WB
Host: Rabbit
Species reactivity: human, mouse, rat
From 352.00€ *
Review
Anti-DNA Ligase IV [KO Validated]
Anti-DNA Ligase IV [KO Validated]

Item number: G-CAB18050.100

Protein function: DNA ligase involved in DNA non-homologous end joining (NHEJ), required for double-strand break (DSB) repair and V(D)J recombination (PubMed:8798671, PubMed:9242410, PubMed:9809069, PubMed:12517771, PubMed:17290226). Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing...
Keywords: Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4, [KO Validated] DNA Ligase IV Rabbit pAb
Application: WB, IF
Host: Rabbit
Species reactivity: human, mouse
From 352.00€ *
Review
Anti-LIG4
Anti-LIG4

Item number: ATA-HPA001334.100

Protein function: Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non- homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and...
Keywords: Anti-LIG4, Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4
Application: IHC
Host: Rabbit
Species reactivity: human
From 300.00€ *
Review
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