L-838,417

L-838,417 is a partial agonist of alpha2-, alpha3-, and alpha5 subunit-containing GABAA receptors. It potentiates GABA-induced currents in LTK- cells expressing alpha2beta3gamma2, alpha3beta3gamma2, or alpha5beta3gamma2 subunit-containing GABAA receptors when used at a concentration of 100 nM. In vivo, L-838,417 (10 mg/kg) increases the mechanical paw withdrawal threshold in a rat model of spinal nerve ligation-induced static allodynia. It also decreases social avoidance in a novel environment in adult and adolescent rats, indicating anxiolytic-like activity, when administered at doses of 1 and 2 mg/kg, respectively.Formal Name: 3-(2,5-difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine. CAS Number: 286456-42-6. Molecular Formula: C19H19F2N7O. Formula Weight: 399.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: FC(C=CC(F)=C1)=C1C2=NN=C3N2N=C(OCC4=NC=NN4C)C(C(C)(C)C)=C3. InChi Code: InChI=1S/C19H19F2N7O/c1-19(2,3)13-8-15-24-25-17(12-7-11(20)5-6-14(12)21)28(15)26-18(13)29-9-16-22-10-23-27(16)4/h5-8,10H,9H2,1-4H3. InChi Key: BQDUNOMMYOKHEP-UHFFFAOYSA-N.