KYA1797K

KYA1797K is an inhibitor of Wnt/beta-catenin signaling. It inhibits expression of a reporter induced by Wnt3a-conditioned medium in HEK293 cells (IC50 = 0.75 µM). KYA1797K binds to the regulators of G-protein signaling (RGS) domain of axin and increases activation of GSK3beta, as well as phosphorylation of beta-catenin and Ras, in HEK293 cells when used at a concentration of 25 µM. It decreases beta-catenin and Ras protein levels and inhibits colony formation in SW480 cells in a concentration-dependent manner. KYA1797K inhibits the growth of SW480, LoVo, DLD1, and HCT15 cells (GI50s = 5, 4.8, 4.5, and 4.2 µM, respectively). It reduces tumor growth in a D-MT colorectal cancer mouse xenograft model when administered at a dose of 20 mg/kg.Formal Name: (5Z)-5-[[5-(4-nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid, monopotassium salt. CAS Number: 1956356-56-1. Molecular Formula: C17H11N2O6S2 . K. Formula Weight: 442.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: Partially soluble, DMSO: 0.5 mg/ml, Ethanol: Partially soluble, PBS (pH 7.2): 0.3 mg/ml. lambdamax: 240, 327, 436 nm. SMILES: O=C(N(CCC([O-])=O)C(S/1)=S)C1=C\C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2.[K+]. InChi Code: InChI=1S/C17H12N2O6S2.K/c20-15(21)7-8-18-16(22)14(27-17(18)26)9-12-5-6-13(25-12)10-1-3-11(4-2-10)19(23)24,/h1-6,9H,7-8H2,(H,20,21),/q,+1/p-1/b14-9-,. InChi Key: PHUNRLYHXGMOLG-WQRRWHLMSA-M.