KX2-391

KX2-391 is an inhibitor of Src kinase (IC50 = ~20 nM). It is selective for Src over PDGFR, EGFR, JAK1, JAK2, Lck, and ZAP-70. KX2-391 induces cell cycle arrest at the G2/M phase and apoptosis in breast cancer cells expressing estrogen receptor alpha (ERalpha). It inhibits the growth of Huh7, PLC/PRF/5, Hep3B, and HepG2 cells (GI50s = 9, 13, 26, and 60 nM, respectively). KX2-391 (10 mg/kg) decreases spleen weight and the number of splenic leukemia cells in a mouse model of FLT3 bearing internal-tandem duplication and F691L mutant (FLT3-ITD-F691L) acute myeloid leukemia (AML).Formal Name: 5-[4-[2-(4-morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-2-pyridineacetamide. CAS Number: 897016-82-9. Synonyms: KX 01, Tirbanibulin. Molecular Formula: C26H29N3O3. Formula Weight: 431.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 268 nm. SMILES: O=C(CC1=NC=C(C2=CC=C(OCCN3CCOCC3)C=C2)C=C1)NCC4=CC=CC=C4. InChi Code: InChI=1S/C26H29N3O3/c30-26(28-19-21-4-2-1-3-5-21)18-24-9-6-23(20-27-24)22-7-10-25(11-8-22)32-17-14-29-12-15-31-16-13-29/h1-11,20H,12-19H2,(H,28,30). InChi Key: HUNGUWOZPQBXGX-UHFFFAOYSA-N.