(±)-Ketoprofen

(±)-Ketoprofen is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID). It inhibits human recombinant COX-1 and COX-2 with IC50 values of 0.5 and 2.33 µM, respectively. In vivo, (±)-ketoprofen reduces carrageenan-induced paw edema and increases latency to paw withdrawal in the hot plate test in rats when administered using a sustained-release implant. Formulations containing (±)-ketoprofen have been used to treat pain and inflammation in osteoarthritis.Formal Name: 3-benzoyl-alpha-methyl-benzeneacetic acid. CAS Number: 22071-15-4. Synonyms: (R,S)-Ketoprofen, 2-(3-benzoylphenyl)Propionic Acid. Molecular Formula: C16H14O3. Formula Weight: 254.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): .5 mg/ml. lambdamax: 254 nm. SMILES: O=C(C1=CC=CC=C1)C2=CC=CC(C(C)C(O)=O)=C2. InChi Code: InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19). InChi Key: DKYWVDODHFEZIM-UHFFFAOYSA-N.