Kdo2-Lipid A (sodium salt)

Kdo2-Lipid A is the active component of LPS. It selectively induces Il-6 expression in wild-type RAW 264.7 macrophages, but not Tlr4-/- RAW 264.7 macrophages, when used at a concentration of 1 µg/ml. Kdo2-Lipid A (100 ng/ml) increases the levels of prostaglandin D2 (PGD2, Cay-12010), PGE2 (Cay-14010), and Tnf-alpha in RAW 264.7 macrophages to a similar extent as LPS. It has been used in lipidomic studies to assess changes in lipid expression and metabolism induced by immune activation in macrophages.Formal Name: 1-(dihydrogen phosphate) 3-[(3R)-3-hydroxytetradecanoate] O-3-deoxy-alpha-D-manno-2-octulopyranosonosyl-(2->4)-O-3-deoxy-alpha-D-manno-2-octulopyranosonosyl-(2->6)-O-2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxododecyl)oxy]tetradecyl]amino]-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-alpha-D-glucopyranose, tetrasodium salt. Synonyms: KLA. Molecular Formula: C110H198N2O39P2 . 4Na. Formula Weight: 2326.7. Formulation: (Request formulation change), A solution in pyrogen-free double distilled water. Solubility: Water: Soluble. SMILES: O=P(O)([O-])O[C@@H](O1)[C@H](NC(C[C@@H](CCCCCCCCCCC)O)=O)[C@@H](OC(C[C@@H](CCCCCCCCCCC)O)=O)[C@H](O)[C@H]1CO[C@H]2[C@H](NC(C[C@@H](CCCCCCCCCCC)OC(CCCCCCCCCCC)=O)=O)[C@@H](OC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)[C@H](OP(O)([O-])=O)C(CO[C@@]3(C([. InChi Code: InChI=1S/C110H202N2O39P2.4Na/c1-7-13-19-25-31-37-38-44-50-56-62-68-92(123)142-82(66-60-54-48-42-35-29-23-17-11-5)72-94(125)146-104-96(112-90(121)71-81(65-59-53-47-41-34-28-22-16-10-4)141-91(122)67-61-55-49-43-36-30-24-18-12-6)105(144-88(102(104)150-1. InChi Key: LCJLFVJYTHXFIW-NURNXRJXSA-J.