JNJ-1661010

Fatty acid amide hydrolase (FAAH) degrades N-acyl ethanolamines, including the endocannabinoid arachidonoyl ethanolamide (AEA). JNJ-1661010 is a selective inhibitor of FAAH (IC50s = 34 and 33 nM in rat and human, respectively) that is able to cross the blood-brain barrier. At 20 mg/kg, JNJ-1661010 has been shown to elevate levels of AEA in rat brain. This compound has been used to examine the contribution of endocannabinoid signaling in experimental fibrosis.Formal Name: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide. CAS Number: 681136-29-8. Molecular Formula: C19H19N5OS. Formula Weight: 365.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml, DMSO: 20 mg/ml, Ethanol: 1.5 mg/ml. lambdamax: 245 nm. SMILES: O=C(NC1=CC=CC=C1)N2CCN(C3=NC(C4=CC=CC=C4)=NS3)CC2. InChi Code: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25). InChi Key: BHBOSTKQCZEAJM-UHFFFAOYSA-N.