IOX2

IOX2 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2, IC50 = 21 nM) with over 100-fold selectivity compared to inhibition of JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH (IC50s > 100 µM). IOX2 is active in cells, inhibiting HIF-1alpha hydroxylation in RCC4 cells at 50 µM. See the Structural Genomics Consortium (SGC) website for more information.Formal Name: N-[[1,2-dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine. CAS Number: 931398-72-0. Molecular Formula: C19H16N2O5. Formula Weight: 352.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 5 mg/ml. lambdamax: 232, 289, 331 nm. SMILES: OC(C1=CC=CC=C1N2CC3=CC=CC=C3)=C(C(NCC(O)=O)=O)C2=O. InChi Code: InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23). InChi Key: CAOSCCRYLYQBES-UHFFFAOYSA-N.