Imipramine (hydrochloride)

Imipramine is a first generation tricyclic antidepressant. It inhibits serotonin (5-HT) uptake by isolated human platelets by 54 and 79% when used at concentrations of 1 and 4 µg/ml, respectively, and inhibits norepinephrine uptake in rat brain by 63% when administered at a dose of 20 mg/kg. It also binds to histamine H1, M1 muscarinic acetylcholine, and alpha1-adrenergic receptors (Kds = 37, 46, and 32 nM, respectively). Imipramine (10 and 20 µM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide (Cay-10681). Formulations containing imipramine have been used in the treatment of depression and as an adjunct in the treatment of childhood enuresis.Formal Name: 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine, monohydrochloride. CAS Number: 113-52-0. Synonyms: Melipramine. Molecular Formula: C19H24N2 . HCl. Formula Weight: 316.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 212, 250 nm. SMILES: CN(C)CCCN1C2=C(C=CC=C2)CCC3=C1C=CC=C3.Cl. InChi Code: InChI=1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21,/h3-6,8-11H,7,12-15H2,1-2H3,1H. InChi Key: XZZXIYZZBJDEEP-UHFFFAOYSA-N.