Imidaprilat
| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| Cay38046-500 | 500 µg | - |
6 - 10 business days* |
213.00€
|
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| Cay38046-1 | 1 mg | - |
6 - 10 business days* |
383.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Imidaprilat is an inhibitor of angiotensin-converting enzyme (ACE, IC50 = 2.6 nM) and an active... more
Product information "Imidaprilat"
Imidaprilat is an inhibitor of angiotensin-converting enzyme (ACE, IC50 = 2.6 nM) and an active metabolite of the prodrug imidapril (Cay-18854). It inhibits bradykinin-induced contractions in isolated guinea pig ileum (IC50 = 1.7 nM). Imidaprilat (50 nM) reduces adhesion induced by chemokine (C-C-) motif ligand 2 (CCL2) of THP-1 monocytes to TNF-alpha-activated human umbilical vein endothelial cells (HUVECs). In vivo, imidaprilat (1 mg/kg) inhibits the angiotensin I-induced pressor response in unanesthetized normotensive rats.Formal Name: 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4S-imidazolidinecarboxylic acid. CAS Number: 89371-44-8. Synonyms: 6366A. Molecular Formula: C18H23N3O6. Formula Weight: 377.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=C1N(C([C@H](C)N[C@@H](CCC2=CC=CC=C2)C(O)=O)=O)[C@H](C(O)=O)CN1C. InChi Code: InChI=1S/C18H23N3O6/c1-11(15(22)21-14(17(25)26)10-20(2)18(21)27)19-13(16(23)24)9-8-12-6-4-3-5-7-12/h3-7,11,13-14,19H,8-10H2,1-2H3,(H,23,24)(H,25,26)/t11-,13-,14-/m0/s1. InChi Key: VFAVNRVDTAPBNR-UBHSHLNASA-N.
| Keywords: | 6366A, 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4S-imidazolidinecarboxylic acid |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 38046 |
Properties
| Application: | ACE inhibitor, active imidapril metabolite |
| MW: | 377.4 D |
| Formula: | C18H23N3O6 |
| Purity: | >95% |
| Format: | Solid |
Database Information
| CAS : | 89371-44-8| Matching products |
| KEGG ID : | K01283 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | -20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H312, H315, H319, H332 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P361+364, P362+364, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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