ICI 192605

ICI 192605 is a potent antagonist of the thromboxane A2 receptor (TP) that blocks contraction of isolated guinea pig trachea induced by U-46619 (Cay-16450, Kd = 0.398 nM). It is used to study the role of TP signaling in tissues and animals.Formal Name: (4Z)-rel-6-[(2R,4R,5S)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-4-hexenoic acid. CAS Number: 117621-64-4. Molecular Formula: C22H23ClO5. Formula Weight: 402.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 25 mg/ml. lambdamax: 274 nm. SMILES: OC1=C(C=CC=C1)[C@H]2O[C@H](OC[C@H]2C/C=C\CCC(O)=O)C3=C(Cl)C=CC=C3. InChi Code: InChI=1S/C22H23ClO5/c23-18-11-6-4-9-16(18)22-27-14-15(8-2-1-3-13-20(25)26)21(28-22)17-10-5-7-12-19(17)24/h1-2,4-7,9-12,15,21-22,24H,3,8,13-14H2,(H,25,26)/b2-1-/t15-,21+,22+/m1/s1. InChi Key: WHUIENZXNGAHQI-GKZDNZBASA-N.