35 products were found matching "K04264"!

U-46619 is a stable analog of the endoperoxide prostaglandin H2, and a TP receptor agonist. It exhibits properties similar to thromboxane A2, causing platelet shape change and aggregation, and contraction of vascular smooth muscle. Mean EC50 values for shape change in human, rat, and rabbit platelets are 4.8, 6.0,...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: TBXA2R, TXA2-R, BDPLT13, prostanoid TP receptor

Recombinant HEK293 cells stably overexpress human thromboxane A2 receptor (TBXA2R) on the surface and contain high level of G protein Galphai and Galphaq to couple with the receptor in downstream signaling pathways.

Seratrodast is a potent antagonist of the thromboxane A2 (TXA2) receptor (TP), blocking specific binding of U-46619 (Cay-16450) to guinea pig platelets with an IC50 value of 7.4 nM and platelet aggregation induced by U-44069 (Cay-16440) with an IC50 value of 350 nM. It is metabolized, in liver microsomes, by...

Thromboxane A2 (TXA2) is a potent vasoconstrictor and activator of platelet aggregation. TXA2 elicits its effects via a 7-transmembrane domain G protein-coupled receptor, the TP receptor. The TP receptor is highly expressed in platelets and is relatively less abundant in tissues such as lung, kidney, brain, spleen,...

The lipid mediator thromboxane A2 (TXA2) plays a key role in platelet aggregation and vascular and bronchial smooth muscle constriction. The actions of TXA2 are mediated by its specific G protein coupled-receptor, referred to as the TXA2 receptor or TP. S18886 is an orally active, long-acting antagonist of the TP...

U-44069 is a stable analog of the endoperoxide PGH2 (Cay-17020) and a TP receptor agonist. It stimulates shape change in human platelets without a measurable increase in Ca2+ with an EC50 value of 1.8 nM. U-44069 has an EC50 value of 3 µM and 54 nM for platelet aggregation and phosphatidate formation in human...

This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene....

A thromboxane receptor antagonist used primarily in the treatment of asthma.

Daltroban is a thromboxane receptor (TP) antagonist. It inhibits aggregation of isolated human platelets induced by the TP agonist U-46619 (Item no. 16450, IC50 = 77 nM). Daltroban increases mean pulmonary arterial pressure (MPAP), mean arterial pressure (MAP), and hematocrit levels in anesthetized rats (ED50s = 20,...

Description: U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (SM) of mice with a myosin light chain 9 (Myl9) gene deletion. Target: PPAR, Progesterone Receptor. Smiles:...

A thromboxane receptor antagonist, a CRTH2 antagonist. It is indicated for the treatment of coronary artery disease. It has also been used for the treatment of asthma. Also prostaglandin D2 receptor antagonist.