ICA 110381

ICA 110381 is an activator of voltage-gated potassium channel Kv7.2. It induces rubidium efflux in an agonist-induced rubidium efflux assay using CHO cells (EC50 = 0.38 µM for the human channel). ICA 110381 also inhibits rubidium efflux from CHO cells expressing Kv7.1 (EC50 = 15 µM for the human channel). It reduces seizure number and increases the current threshold for seizure induction by amygdala-kindling in rats when administered at a dose of 30 mg/kg.Formal Name: 4-chloro-N-(6-chloro-3-pyridinyl)-benzamide. CAS Number: 325457-99-6. Molecular Formula: C12H8Cl2N2O. Formula Weight: 267.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 25 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml. lambdamax: 268 nm. SMILES: O=C(C1=CC=C(C=C1)Cl)NC2=CN=C(Cl)C=C2. InChi Code: InChI=1S/C12H8Cl2N2O/c13-9-3-1-8(2-4-9)12(17)16-10-5-6-11(14)15-7-10/h1-7H,(H,16,17). InChi Key: FOYOGIUAMYSVIT-UHFFFAOYSA-N.