33 products were found matching "K04927"!
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Retigabine (exempt preparation)
Item number: Cay40314-1
Retigabine (exempt preparation) (Cay-40314) is an analytical reference standard categorized as a positive allosteric modulator (PAM) of KCNQ2-5 (Kv7.2-7.5) potassium ion channels. Formulations containing retigabine have been used in the treatment of partial epilepsies. Retigabine is regulated as a Schedule V...
| Keywords: | D 23129, Ezogabine, GKE-841, GW 582892X, WAY-143841, N-[2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]-carbamic acid,... |
| Application: | Analytical reference standard, KCNQ2-5 (Kv7.2-7.5) potassium ion channel PAM |
| CAS | 150812-12-7 |
| MW: | 303.3 D |
108.00€
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ML213
Item number: TGM-T4030-100mg
Description: ML213 (CID-3111211) is a selective activator of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively. Target: Potassium Channel. Smiles: Cc1cc(C)c(NC(=O)C2CC3CCC2C3)c(C)c1. References: Yu, H.,et al. Discovery, synthesis, and...
| Keywords: | CID-3111211 |
| Application: | KCNQ2 / KCNQ4 activator |
| CAS | 489402-47-3 |
| MW: | 257.37 D |
From 52.00€
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ICA 110381
Item number: TGM-T7612-100mg
Description: ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. Target: Potassium Channel. Smiles: C(NC=1C=CC(Cl)=NC1)(=O)C2=CC=C(Cl)C=C2. References: Amato G , Roeloffs R , Rigdon G C , et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment...
| Application: | Kv7.2 (KCNQ2) activator |
| CAS | 325457-99-6 |
| MW: | 267.11 D |
From 42.00€
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Ebio1
Item number: TGM-T84693-10mg
Description: Ebio1, a selective activator of the voltage-gated potassium channel KCNQ2, enhances channel conductance by promoting the formation of an expanded gate at a saturation voltage of +50 mV, leading to increased channel activity [1]. Target: Others. Smiles: N(C(=O)C1=CC=C(F)C=C1)C2=C3C4=C(CCC4=CC=C3)C=C2
| Application: | Kv7.2 activator |
| CAS | 339287-36-4 |
| MW: | 291.32 D |
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ML-252 hydrochloride
Item number: TGM-T85299-10mg
Description: ML-252 is a potent, selective inhibitor of the Kv7.2 voltage-gated potassium channel, demonstrating an IC50 value of 69 nM in patch clamp assays. It exists as the (S)-enantiomer, which is significantly more effective than both its (R)-enantiomer counterpart and the racemic mixture, with respective IC50...
| Application: | KCNQ2 inhibitor |
| CAS | 2309887-61-2 |
| MW: | 344.9 D |
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KCNQ2/3 activator-1
Item number: TGM-T9400-100mg
Description: KCNQ2/3 activator-1 is a Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator, details of which are from Compound A of Patent WO2021113757A1. Target: Others, Potassium Channel. Smiles: Cc1cc(cc(C)c1NC(=O)CC(C)(C)C)N1CCc2cc(F)ccc2C1. References: Paul Robert, et al. Solid state crystalline forms of a...
| Application: | Targets potassium voltage-gated channel KQT-like subfamily member 2 (KCNQ2, KV7.2) |
| CAS | 1009344-33-5 |
| MW: | 368.49 D |
From 34.00€
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XE 991 dihydrochloride
Item number: TGM-T17262-100mg
Description: XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current (IC50s: 0.75 µM, 0.71 µM, 0.6 µM, and 0.98 µM, respectively). Target: Potassium Channel, Others. Smiles:...
| Application: | KCNQ channel blocker |
| CAS | 122955-13-9 |
| MW: | 449.37 D |
From 42.00€
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DMP-543
Item number: TGM-T15143-100mg
Description: DMP-543 (XR-543) is a KV7 channel blocker that enhances neurotransmitter release. Target: Others, Potassium Channel. Smiles: Fc1cc(CC2(Cc3ccnc(F)c3)c3ccccc3C(=O)c3ccccc23)ccn1. References: Ipavec V, et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric...
| Keywords: | XR-543 |
| Application: | Kv7.2 inhibitor |
| CAS | 160588-45-4 |
| MW: | 412.43 D |
From 48.00€
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ICA-27243
Item number: TGM-T15545-100mg
Description: ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 µM). ICA-27243 also has antiepileptic and anticonvulsant effects. Target: Potassium Channel. Smiles: Fc1ccc(cc1F)C(=O)Nc1ccc(Cl)nc1. References: Wickenden...
| Application: | Kv7.2/Kv7.3 subunit-containing channels activator |
| CAS | 325457-89-4 |
| MW: | 268.65 D |
From 37.00€
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XE 991 (hydrochloride)
Item number: Cay14582-10
The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 µM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 µM). It much...
| Keywords: | 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone, dihydrochloride |
| Application: | KCNQ channel blocker |
| CAS | 122955-13-9 |
| MW: | 449.4 D |
From 85.00€
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Linopirdine
Item number: Cay19547-1
Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking voltage-gated, calcium-activated and leak (M-type, Kv7.2/7.3, KCNQ2/3) K+...
| Keywords: | DuP-996, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one |
| Application: | Nootropic, cognition enhancer |
| CAS | 105431-72-9 |
| MW: | 391.5 D |
From 44.00€
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ML-213
Item number: Cay15185-10
The KCNQ (Kv7) family of voltage-gated potassium (K+) channels consists of five members, KCNQ1-KCNQ5. KCNQ1-KCNQ5 are critical for setting up the excitation threshold of action potentials. KCNQ1 is expressed mainly in cardiac tissue, peripheral epithelial cells, and smooth muscle cells, while KCNQ2-KCNQ5 are...
| Keywords: | CID-3111211, N-(2,4,6-trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide |
| Application: | KCNQ2 / KCNQ4 activator |
| CAS | 489402-47-3 |
| MW: | 257.4 D |
From 94.00€
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