HNMPA

HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity. It does not affect protein kinase C or cyclic AMP-dependent protein kinase activities. HNMPA inhibits the insulin-stimulated autophosphorylation of the 95-kDa beta-subunit of the insulin receptor with an IC50 value of 200 µM in vitro.Formal Name: P-(hydroxy-2-naphthalenylmethyl)-phosphonic acid. CAS Number: 132541-52-7. Synonyms: Hydroxy-2-naphthalenylmethyl Phosphonic Acid. Molecular Formula: C11H11O4P. Formula Weight: 238.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 1 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 228 nm. SMILES: OC(P(O)(O)=O)C1=CC2=CC=CC=C2C=C1. InChi Code: InChI=1S/C11H11O4P/c12-11(16(13,14)15)10-6-5-8-3-1-2-4-9(8)7-10/h1-7,11-12H,(H2,13,14,15). InChi Key: AMJJLDJPDLKNJA-UHFFFAOYSA-N.