143 products were found matching "K04527"!

Product Description: Insulin receptor (INSR) is a transmembrane receptor tyrosine kinase that plays a central role in mediating the effects of insulin on glucose homeostasis and metabolism. Structurally, the mature receptor is a tetramer composed of two extracellular alpha-subunits, responsible for insulin binding,...

Product Description: Insulin receptor (INSR) is a transmembrane receptor tyrosine kinase that plays a central role in mediating the effects of insulin on glucose homeostasis and metabolism. Structurally, the mature receptor is a tetramer composed of two extracellular alpha-subunits, responsible for insulin binding,...

Product Description: Insulin receptor (INSR) is a transmembrane receptor tyrosine kinase that plays a central role in mediating the effects of insulin on glucose homeostasis and metabolism. Structurally, the mature receptor is a tetramer composed of two extracellular alpha-subunits, responsible for insulin binding,...

Description: Insulin Receptor Protein, Mouse, Recombinant (His) is expressed in HEK293 Cells. The accession number is P15208.

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it...

H-Asn-Pro-Glu-Tyr(PO3H2)-OH is a phosphorylated peptide derivative of the tetramine motif Asn-Pro-Glu-Tyr (NPEY), which is found in the insulin receptor beta (InsRbeta) submembrane domain and is phosphorylated at Tyr972 upon insulin binding. InChI:...

The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) promotes cell growth while inhibiting apoptotic pathways. Overexpression of IGF-1R is found in certain solid tumors and hematologic neoplasias. However, insulin receptor (InsR) signaling can compensate for IGF-1R inhibition....

Protein function: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated...

Potent protein phosphotyrosine phosphatase inhibitor Insulin receptor kinase (IRK) inducer, Insulin mimetic in vitro and in vivo, Apoptosis inducer, ERK inducer, Mitogen-activated protein kinase phosphatase-1 (MKP-1) inducer, Angiogenesis inhibitor.

Protein function: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated...

BMS 754807 is a reversible, orally bioavailable dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases (IC50s = 1.8 and 1.7 nM, respectively). It has minimal effect against an array of other tyrosine and serine/threonine kinases. BMS 754807 inhibits cell...

GSK-1904529A is an inhibitor of the insulin receptor (InsR) and IGF-1R that exhibits anticancer chemotherapeutic activity. In cellular and animal models of multiple myeloma and Ewing's sarcoma, GSK-1904529A induces cell cycle arrest and inhibits cell proliferation and tumor growth.