HMB-Val-Ser-Leu-VE

HMB-Val-Ser-Leu-VE is a cell-permeable vinyl ester tripeptide inhibitor of the trypsin-like activity of the 20S proteasome (IC50 = 0.033 µM). It is selective for the trypsin-like activity over the chymotryptic- or post-acidic-like activities (IC50s = >10 µM for both). HMB-Val-Ser-Leu-VE is active against T. brucei (GI50 = 31.6 µM).Formal Name: N-(3-hydroxy-2-methylbenzoyl)-L-valyl-N-[(1S,2E)-4-ethoxy-1-(2-methylpropyl)-4-oxo-2-butenyl]-L-serinamide. CAS Number: 862891-04-1. Molecular Formula: C26H39N3O7. Formula Weight: 505.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2)(1:10): .5 mg/ml. lambdamax: 210 nm. SMILES: OC1=CC=CC(C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)/C=C/C(OCC)=O)=O)=O)=O)=C1C. InChi Code: InChI=1S/C26H39N3O7/c1-7-36-22(32)12-11-18(13-15(2)3)27-25(34)20(14-30)28-26(35)23(16(4)5)29-24(33)19-9-8-10-21(31)17(19)6/h8-12,15-16,18,20,23,30-31H,7,13-14H2,1-6H3,(H,27,34)(H,28,35)(H,29,33)/b12-11+/t18-,20+,23+/m1/s1. InChi Key: YQKMRGLFGXKLJC-VOSPOJDESA-N.