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Item number: Cay10007713-1

HMB-Val-Ser-Leu-VE is a cell-permeable vinyl ester tripeptide inhibitor of the trypsin-like activity of the 20S proteasome (IC50 = 0.033 µM). It is selective for the trypsin-like activity over the chymotryptic- or post-acidic-like activities (IC50s = >10 µM for both). HMB-Val-Ser-Leu-VE is active against T. brucei...

Keywords:	N-(3-hydroxy-2-methylbenzoyl)-L-valyl-N-[(1S,2E)-4-ethoxy-1-(2-methylpropyl)-4-oxo-2-butenyl]-L-serinamide
Application:	20S proteasome inhibitor
CAS	862891-04-1
MW:	505.6 D

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