HIF-2alpha Antagonist 2
| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| Cay16971-1 | 1 mg | - |
6 - 10 business days* |
52.00€
|
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| Cay16971-5 | 5 mg | - |
6 - 10 business days* |
114.00€
|
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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
HIF-2alpha antagonist 2 is an inhibitor of hypoxia-inducible factor-2alpha (HIF-2alpha) PAS-B... more
Product information "HIF-2alpha Antagonist 2"
HIF-2alpha antagonist 2 is an inhibitor of hypoxia-inducible factor-2alpha (HIF-2alpha) PAS-B domain heterodimerization. It binds to the HIF-2alpha PAS-B domain (Kd = 81 nM) to inhibit heterodimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT) PAS-B domain in cell-free assays when used at concentrations ranging from 0.1 to 100 µM. HIF-2alpha antagonist 2 (0.1-30 µM) decreases expression of the HIF-2alpha target gene VEGFA in 786-O renal carcinoma cells.Formal Name: N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine. CAS Number: 1422955-31-4. Molecular Formula: C12H6ClFN4O3. Formula Weight: 308.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 30 mg/ml. SMILES: ClC1=CC(F)=CC(NC2=C([N+]([O-])=O)C3=NON=C3C=C2)=C1. InChi Code: InChI=1S/C12H6ClFN4O3/c13-6-3-7(14)5-8(4-6)15-10-2-1-9-11(17-21-16-9)12(10)18(19)20/h1-5,15H. InChi Key: CDQUJZKBRAFWNG-UHFFFAOYSA-N.
| Keywords: | N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 16971 |
Properties
| Application: | EPAS-1 PAS-B domain heterodimerization inhibitor |
| MW: | 308.7 D |
| Formula: | C12H6ClFN4O3 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 1422955-31-4| Matching products |
| KEGG ID : | K09095 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301, H413 |
| P Phrases: | P264, P270, P273, P321, P330, P301+P310, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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