HG-10-102-01

HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 = 20.3 nM). It also inhibits the G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50s = 3.2, 153, and 95.9 nM, respectively). HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells. When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen.Formal Name: [4-[[5-chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone. CAS Number: 1351758-81-0. Molecular Formula: C17H20ClN5O3. Formula Weight: 377.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/mL, DMSO: 30 mg/mL, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL, Ethanol: 0.3 mg/mL. lambdamax: 225, 275, 309 nm. SMILES: O=C(C1=CC(OC)=C(NC2=NC=C(Cl)C(NC)=N2)C=C1)N3CCOCC3. InChi Code: InChI=1S/C17H20ClN5O3/c1-19-15-12(18)10-20-17(22-15)21-13-4-3-11(9-14(13)25-2)16(24)23-5-7-26-8-6-23/h3-4,9-10H,5-8H2,1-2H3,(H2,19,20,21,22). InChi Key: YEVOZZZLKJKCCD-UHFFFAOYSA-N.