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Item number: Cay20049-1

HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 = 20.3 nM). It also inhibits the G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50s = 3.2, 153, and 95.9 nM, respectively). HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant...

Keywords:	[4-[[5-chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone
Application:	LRRK2 inhibitor
CAS	1351758-81-0
MW:	377.8 D

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