HC-067047

HC-067047 is a TRPV4 antagonist that reversibly inhibits currents through human, rat, and mouse TRPV4 orthologs (IC50s = 48, 133, and 17 nM, respectively). It is selective for TRPV4 over TRPV1, TRPV2, TRPV3, and TRPM8 channels. HC-067047 has been shown to increase functional bladder capacity and to reduce micturition frequency in wild-type mice and rats with cystitis.Formal Name: 2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide. CAS Number: 883031-03-6. Molecular Formula: C26H28F3N3O2. Formula Weight: 471.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml, DMSO: 15 mg/ml, Ethanol: 1 mg/ml. lambdamax: 279 nm. SMILES: CC1=C(C(NC2=CC=CC(C(F)(F)F)=C2)=O)C=C(C3=CC=CC=C3)N1CCCN4CCOCC4. InChi Code: InChI=1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33). InChi Key: NCZYSQOTAYFTNM-UHFFFAOYSA-N.