HA-14-1

HA-14-1 is a small molecule that binds the surface pocket of Bcl-2 proteins (IC50 = ~ 9 µM) and induces apoptosis by interfering with its interaction with the Bak peptide and activating Apaf-1 and caspase-9 and -3. It can also bind to the antiapoptotic Bcl-2 proteins Bcl-xl and Bcl-W. HA-14-1 has been shown to induce apoptosis of human acute myeloid leukemia (HL-60) cells (50 µM induces 90% loss of viability).Formal Name: (alphaR,4R)-rel-2-amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid, ethyl ester. CAS Number: 927635-64-1. Molecular Formula: C17H17BrN2O5. Formula Weight: 409.2. Purity: >95% (mixture of isomers). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 16 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2) (1:9): 0.1 mg/ml. lambdamax: 230, 274 nm. SMILES: NC1=C(C(OCC)=O)C(C(C#N)C(OCC)=O)C2=CC(Br)=CC=C2O1. InChi Code: InChI=1S/C17H17BrN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3. InChi Key: SXJDCULZDFWMJC-UHFFFAOYSA-N.