GW590735, Free Acid

GW590735, Free Acid
Item number Size Datasheet Manual SDS Delivery time Quantity Price
LC-G-7322_5mg 5 mg -

3 - 15 business days*

102.00€
LC-G-7322_10mg 10 mg -

3 - 15 business days*

128.00€
LC-G-7322_25mg 25 mg -

3 - 15 business days*

208.00€
LC-G-7322_50mg 50 mg -

3 - 15 business days*

323.00€
LC-G-7322_100mg 100 mg -

3 - 15 business days*

458.00€
LC-G-7322_300mg 300 mg -

3 - 15 business days*

1,019.00€
LC-G-7322_500mg 500 mg -

3 - 15 business days*

1,381.00€
 
Soluble in DMSO. GW590735 is a potent and selective PPARalpha agonist. It stimulated PPARalpha... more
Product information "GW590735, Free Acid"
Soluble in DMSO. GW590735 is a potent and selective PPARalpha agonist. It stimulated PPARalpha with an EC50 of 4 nM and had at least 500-fold selectivity on PPARalpha versus PPARdelta and PPARgamma. It raised circulating levels of high-density lipoprotein cholesterol. Sierra M.L., et al. 'Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonist. 1. Discovery of a novel series of potent HDLc raising agents.' J. Med. Chem. 50(4): 685-695 (2007). GW590735 potently increased high-density lipoprotein (HDL) cholesterol, decreased low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL) cholesterol, and significantly lowered triglycerides in human ApoB100/human CETP transgenic mice. Hansen M.K., et al. 'Selective CETP inhibition and PPARalpha agonism increase HDL cholesterol and reduce LDL cholesterol in human ApoB100/human CETP transgenic mice.' J. Cardiovasc. Pharmacol. Ther. 15(2): 196-202 (2010). Circulating FGF21 significantly increased in response to treatment with PPAR alpha (39%) and PPAR delta (32%), but not PPAR gamma agonist in humans. Christodoulides C., et al. 'Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonist but not ketosis in man.' J. Clin. Endocrinol. Metab. 94(9): 3594-3601 (2009).
Supplier: LC Laboratories
Supplier-Nr: G-7322

Properties

Application: Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist
MW: 478.48 D
Formula: C23H21F3N2O4S
Purity: >99%
Format: Solid

Database Information

CAS : 622402-22-6| Matching products
KEGG ID : K07294 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302+H312+H332
P Phrases: P262
Caution
Our products are for laboratory research use only: Not for administration to humans!
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