GSK963

GSK963 is an inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK1). It is selective for RIPK1 with less than 50% inhibition of 339 kinases in a panel at 10 µM. Unlike the RIPK1 inhibitor necrostatin-1 (Cay-11658), GSK963 is inactive against indolamine-2,3-dioxygenase (IDO). GSK963 inhibits necroptosis induced by TNF in the presence of the caspase inhibitor zVAD in L-929 mouse and U937 human cells (IC50s = 1 and 4 nM, respectively). It also inhibits RIPK1-mediated lethal hypothermia induced by TNF with zVAD in mice when administered at a dose of 2 mg/kg in a model of sterile shock.Formal Name: 1-[(5S)-4,5-dihydro-5-phenyl-1H-pyrazol-1-yl]-2,2-dimethyl-1-propanone. CAS Number: 2049868-46-2. Molecular Formula: C14H18N2O. Formula Weight: 230.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: CC(C)(C)C(N1[C@H](C2=CC=CC=C2)CC=N1)=O. InChi Code: InChI=1S/C14H18N2O/c1-14(2,3)13(17)16-12(9-10-15-16)11-7-5-4-6-8-11/h4-8,10,12H,9H2,1-3H3/t12-/m0/s1. InChi Key: NJQVSLWJBLPTMD-LBPRGKRZSA-N.