GSK840

GSK840 is a receptor-interacting serine/threonine kinase 3 (RIPK3) inhibitor (IC50 = 0.3 nM). It is selective for RIPK3 over a panel of 300 additional kinases at 1 µM. GSK840 (0.04-1 µM) inhibits TNF-alpha-induced necroptosis in primary human neutrophils isolated from human whole blood. It also inhibits LPS-induced neutrophil accumulation in D. rerio larvae.Formal Name: 4-[5-[(methylamino)carbonyl]-1H-benzimidazol-1-yl]-benzeneacetic acid, 1,1-dimethylethyl ester. CAS Number: 2361146-30-5. Molecular Formula: C21H23N3O3. Formula Weight: 365.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: O=C(C1=CC=C2N(C(C=C3)=CC=C3CC(OC(C)(C)C)=O)C=NC2=C1)NC. InChi Code: InChI=1S/C21H23N3O3/c1-21(2,3)27-19(25)11-14-5-8-16(9-6-14)24-13-23-17-12-15(20(26)22-4)7-10-18(17)24/h5-10,12-13H,11H2,1-4H3,(H,22,26). InChi Key: UGTLDBJIOSYXRR-UHFFFAOYSA-N.