GSK837149A

A number of tumor cells and cell lines have been observed to have highly upregulated expression and activity of fatty acid synthase (FASN). GSK837149A is a selective, reversible inhibitor of FASN (IC50 = 15.8 nM). It acts by inhibiting the beta-ketoacyl reductase activity of FASN.Formal Name: 4,4'-(carbonyldiimino)bis[N-(4-methyl-2-pyrimidinyl)-benzenesulfonamide. CAS Number: 13616-29-0. Molecular Formula: C23H22N8O5S2. Formula Weight: 554.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 5 mg/ml. lambdamax: 288 nm. SMILES: CC1=CC=NC(NS(C2=CC=C(NC(NC3=CC=C(S(NC4=NC=CC(C)=N4)(=O)=O)C=C3)=O)C=C2)(=O)=O)=N1. InChi Code: InChI=1S/C23H22N8O5S2/c1-15-11-13-24-21(26-15)30-37(33,34)19-7-3-17(4-8-19)28-23(32)29-18-5-9-20(10-6-18)38(35,36)31-22-25-14-12-16(2)27-22/h3-14H,1-2H3,(H,24,26,30)(H,25,27,31)(H2,28,29,32). InChi Key: RSINKZJTTORDAJ-UHFFFAOYSA-N.