GSK2636771

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of phosphatidylinositol at the 3 position to produce the second messengers phosphatidylinositol-3,4-bisphosphate (PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3). Class 1 PI3Ks are composed of a p110 catalytic subunit, of which there are four isoforms (p110alpha, p110beta, p110delta, and p100gamma), and a p85 regulatory subunit. GSK2636771 is an orally bioavailable inhibitor of PI3K p110beta. At 1-10 µM, it decreases cell viability and Akt phosphorylation in p100beta-dependent PTEN-deficient PC-3 prostate and BT549 and HCC70 breast cancer cell lines.Formal Name: 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid. CAS Number: 1372540-25-4. Molecular Formula: C22H22F3N3O3. Formula Weight: 433.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 245, 345 nm. SMILES: OC(C1=CC(N2CCOCC2)=CC3=C1N=C(C)N3CC4=C(C)C(C(F)(F)F)=CC=C4)=O. InChi Code: InChI=1S/C22H22F3N3O3/c1-13-15(4-3-5-18(13)22(23,24)25)12-28-14(2)26-20-17(21(29)30)10-16(11-19(20)28)27-6-8-31-9-7-27/h3-5,10-11H,6-9,12H2,1-2H3,(H,29,30). InChi Key: XTKLTGBKIDQGQL-UHFFFAOYSA-N.