Glycitein

Glycitein is an O-methylated isoflavone that comprises 5-10% of the total isoflavones in soy food products. This phytoestrogen is reported to have weak estrogenic activity, displacing estradiol binding at the estrogen receptor in vitro with an IC50 value of 3.94 µM. It suppresses the proliferation of osteoblasts and promotes differentiation from its progenitor. It has also been used to attenuate proliferation (10 µM) of aortic smooth muscle cells related to atherosclerotic vascular change in stroke-prone hypertensive rats and to protect against beta amyloid (Abeta)-induced toxicity and oxidative stress (100 µg/ml) in C. elegans expressing human Abeta.Formal Name: 7-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one. CAS Number: 40957-83-3. Molecular Formula: C16H12O5. Formula Weight: 284.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/ml, DMSO: 0.5 mg/ml. lambdamax: 232, 261, 319 nm. SMILES: O=C1C(C2=CC=C(O)C=C2)=COC3=CC(O)=C(OC)C=C31. InChi Code: InChI=1S/C16H12O5/c1-20-15-6-11-14(7-13(15)18)21-8-12(16(11)19)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3. InChi Key: DXYUAIFZCFRPTH-UHFFFAOYSA-N.