Gemfibrozil-d6

Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil (Cay-14835) by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma agonist (EC50s = 193.3 and 147.8 µM, respectively, in transactivation assays). In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-kappaB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice. Formulations containing gemfibrozil have been used in the treatment of high cholesterol.Formal Name: 5-(2,5-dimethylphenoxy)-2,2-di(methyl-d3)-pentanoic acid. CAS Number: 1184986-45-5. Synonyms: CI-719-d6. Molecular Formula: C15H16D6O3. Formula Weight: 256.4. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: OC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])CCCOC1=C(C=CC(C)=C1)C)=O. InChi Code: InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)/i3D3,4D3. InChi Key: HEMJJKBWTPKOJG-LIJFRPJRSA-N.