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You can also order by e-mail: info@biomol.com
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GDC-0032 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoforms alpha, delta, and... more
Product information "GDC-0032"
GDC-0032 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoforms alpha, delta, and gamma (IC50s = 0.28, 0.12, and 0.97 nM, respectively) that is 31 times less potent at PI3Kbeta. It is over 1,000-fold selective for p100alpha over other PI3K-like kinases, including DNA-dependent protein kinase catalytic subunits, ATM, and ATR. GDC-0032 has increased potency in cancer cell lines harboring PIK3CA-activating alterations, and is effective in vivo, suppressing the growth of tumors in a mouse xenograft model at low drug dose levels.Formal Name: 4-[5,6-dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-alpha,alpha-dimethyl-1H-pyrazole-1-acetamide. CAS Number: 1282512-48-4. Synonyms: Taselisib. Molecular Formula: C24H28N8O2. Formula Weight: 460.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 70 mg/mL, Ethanol: <1 mg/mL, Water: <1 mg/mL. lambdamax: 217, 301, 321 nm. SMILES: CC1=NN(C(C)C)C(C2=CN(CCO3)C(C4=C3C=C(C5=CN(C(C)(C)C(N)=O)N=C5)C=C4)=N2)=N1. InChi Code: InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33). InChi Key: BEUQXVWXFDOSAQ-UHFFFAOYSA-N.
Keywords: | Taselisib, 4-[5,6-dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-alpha,alpha-dimethyl-1H-pyrazole-1-acetamide |
Supplier: | Cayman Chemical |
Supplier-Nr: | 17387 |
Properties
Application: | PI3K alpha, delta, gamma inhibitor |
MW: | 460.5 D |
Formula: | C24H28N8O2 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 1282512-48-4| Matching products |
KEGG ID : | K00922 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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