Flunarizine (hydrochloride)

Flunarizine is a calcium antagonist that acts as a potent dilator of peripheral vessels without having calcium-blocking actions in the heart. It reduces calcium fluxes in vascular smooth muscle by blocking both voltage-dependent calcium channels and receptor-operated channels. Flunarizine also acts as a dopamine D2 receptor antagonist. Through its action as a dilator of peripheral vessels, flunarizine has a role in the prophylaxis of migraine headaches.Formal Name: 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-piperazine, dihydrochloride. CAS Number: 30484-77-6. Molecular Formula: C26H26F2N2 . 2HCl. Formula Weight: 477.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 1 mg/ml. lambdamax: 254 nm. SMILES: FC(C=C1)=CC=C1C(C2=CC=C(F)C=C2)N(CC3)CCN3C/C=C/C4=CC=CC=C4.Cl.Cl. InChi Code: InChI=1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21,,/h1-15,26H,16-20H2,2*1H/b7-4+,,. InChi Key: RXKMOPXNWTYEHI-RDRKJGRWSA-N.