- Search results for K04855
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26 products were found matching "K04855"!
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Item number: ELK-EA272.100
Voltage-gated Ca2+ channels (CaV), enable the passage of Ca2+ ions in a voltage dependent manner. These heteromeric entities are formed in part by the pore-forming alpha1 subunit which determines the biophysical and pharmacological properties of the channel. Protein function: Voltage-sensitive calcium channel that...
Keywords: | Anti-Voltage-gated calcium channel subunit alpha Cav3.2, Anti-Low-voltage-activated calcium channel alpha1 3.2 subunit,... |
Application: | IHC |
Host: | Rabbit |
Species reactivity: | human |
283.00€
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Item number: Cay15037-25
Mibefradil is a general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC50 = 2.7 and 18.6 µM, respectively). It is a potent vasodilator, increasing coronary artery flow with an EC50 value of 54 nM. Mibefradil has minimal negative inotropic effects, supporting its use...
Keywords: | Posicor, Ro 40-5967,... |
Application: | Calcium channel blocker, Vasodilator |
CAS | 116666-63-8 |
MW: | 568.6 D |
From 142.00€
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Item number: Cay23947-500
Ethosuximide is an anticonvulsant. It increases glucose, fructose-1,6-bisphosphate, and pyruvate levels in rat brain when administered at a dose of 200 mg/kg. Ethosuximide (400 mg/kg) reduces the severity of audiogenic seizures in a rat model of barbiturate withdrawal-induced convulsions. It also inhibits tonic...
Keywords: | CI-366, NSC 64013, 3-ethyl-3-methyl-2,5-pyrrolidinedione |
Application: | Calcium channel T type blocker, Anticonvulsant |
CAS | 77-67-8 |
MW: | 141.2 D |
From 56.00€
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Item number: Cay20385-1
Flunarizine is a calcium antagonist that acts as a potent dilator of peripheral vessels without having calcium-blocking actions in the heart. It reduces calcium fluxes in vascular smooth muscle by blocking both voltage-dependent calcium channels and receptor-operated channels. Flunarizine also acts as a dopamine D2...
Keywords: | 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-piperazine, dihydrochloride |
Application: | Calcium channel T type blocker |
CAS | 30484-77-6 |
MW: | 477.4 D |
From 48.00€
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Item number: Cay34499-1
(±)-6-Prenylnaringenin ((±)-6-PN) is a flavonoid that has been found in the hop plant, H. lupulus, and has diverse biological activities. It inhibits the T-type voltage-gated calcium (Cav) channel Cav3.2 and high-voltage-activated calcium currents in whole-cell patch-clamp assays using HEK293 cells (IC50s = 0.912...
Keywords: | (±)-6-PN, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one |
Application: | Bioactive flavonoid |
CAS | 68682-01-9 |
MW: | 340.4 D |
From 104.00€
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Item number: 200-301-F11
Anti-CAV3.2 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with CAV3.2 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. No cross-reactivity against Cav1.3. Cross-reactivity with CAV3.2 from other sources has not been determined....
Keywords: | Anti-CACNA1H, Anti-Voltage-gated calcium channel subunit alpha Cav3.2, Anti-Low-voltage-activated calcium channel alpha1... |
Application: | IHC, IFM, IP, WB |
Host: | Mouse |
Species reactivity: | human, mouse, rat |
698.00€
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Item number: 600-401-AA3
Anti-CACNA1H antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. CACNA1H antibody is human, mouse and rat reactive. Multiple isoforms of CACNA1H are known to exist. Protein function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable...
Keywords: | Anti-CACNA1H, Anti-Voltage-gated calcium channel subunit alpha Cav3.2, Anti-Low-voltage-activated calcium channel alpha1... |
Application: | ELISA, WB |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
684.00€
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Item number: Cay26071-1
Penfluridol is a first generation typical antipsychotic that binds to dopamine receptors (IC50 = 5.6 nM). It binds to dopamine D4 receptors and also to serotonin (5-HT) receptors (Kis = 31 and 63.1 nM, respectively). Penfluridol (1.25 and 2.5 mg/kg) inhibits stereotypic behavior induced by apomorphine (Cay-16094) in...
Keywords: | R-16341, 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol |
Application: | Calcium channel T type blocker, Dopamine D4 receptor ligand, Serotonin (5-HT) receptor ligand |
CAS | 26864-56-2 |
MW: | 524 D |
From 50.00€
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Item number: Cay28374-1
Lomerizine is a voltage-dependent calcium channel blocker that inhibits low- and high-voltage activated calcium currents in rat hippocampal CA1 pyramidal neurons with IC50 values of 1.9 and 4 µM, respectively. It inhibits vasoconstriction induced by potassium chloride, serotonin (5-HT, Cay-14332), or vasopressin in...
Keywords: | KB-2796, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-piperazine, dihydrochloride |
Application: | Voltage-dependent calcium channel blocker |
CAS | 101477-54-7 |
MW: | 541.5 D |
From 44.00€
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Item number: Cay28732-25
Carboxyamidotriazole is an orally bioavailable, non-selective calcium channel blocker. It blocks L- and T-type calcium channels in GH3 rat pituitary cancer cells (IC50s = 0.5 and 1.5 µg/ml, respectively). It also inhibits calcium influx stimulated by the acetylcholine receptor agonist carbachol (carbamoylcholine,...
Keywords: | CAI, L-651,582, NSC 609974, 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide |
Application: | Non-selective calcium channel blocker |
CAS | 99519-84-3 |
MW: | 424.7 D |
From 142.00€
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Item number: Cay28742-1
ABT-639 is a T-type calcium channel blocker. It inhibits inactivated-state Cav3.2 channels with an IC50 value of 2.3 µM and inactivated-state Cav3.1 and Cav3.3 channels by 50 and 39%, respectively, when used at a concentration of 10 µM. ABT-639 selectively inhibits inactivated-state T-type calcium currents over...
Keywords: | 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]-benzenesulfonamide |
Application: | T-type calcium channel blocker |
CAS | 1235560-28-7 |
MW: | 455.9 D |
From 60.00€
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Item number: Cay27679-1
Z944 is an inhibitor of T-type calcium channels (IC50s = 0.050-0.160 µM for the human recombinant voltage-gated calcium (Cav) channels Cav3.1, Cav3.2, and Cav3.3). It is selective for T-type channels over the N-type Cav2.2 channel (IC50 = 11 µM), as well as the rat L-type Cav1.2, human-ether-a-go-go (hERG/Kv11.1)...
Keywords: | 4-[[(3-chloro-5-fluorobenzoyl)amino]methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide |
Application: | T-type calcium channel inhibitor |
CAS | 1199236-64-0 |
MW: | 383.9 D |
From 43.00€
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