Fisetin

Fisetin is a flavonoid that has been found in various fruits and vegetables and has diverse biological activities. It scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay and inhibits oxidative burst induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP, Cay-21495) in isolated human polymorphonuclear neutrophils (PMNs) when used at a concentration of 10 µM. Fisetin (10-60 µM) induces cell cycle arrest at the G1 phase and apoptosis in, as well as inhibits the proliferation of, LNCaP prostate cancer cells. It inhibits LPS-induced production of nitrite, prostaglandin E2 (PGE2, Cay-14010), and NF-kappaB activation in RAW 264.7 cells. Fisetin (1 mg/animal) reduces tumor growth in a CWR22Rupsilon1 prostate cancer mouse xenograft model.Formal Name: 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one. CAS Number: 528-48-3. Synonyms: CI-75620, NSC 407010, NSC 656275. Molecular Formula: C15H10O6. Formula Weight: 286.2. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 250, 320, 364 nm. SMILES: O=C1C2=C(C=C(O)C=C2)OC(C3=CC=C(O)C(O)=C3)=C1O. InChi Code: InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H. InChi Key: XHEFDIBZLJXQHF-UHFFFAOYSA-N.