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FH535 is an inhibitor of beta-catenin/Tcf-mediated transcription and an antagonist of ligand-dependent activation of PPARgamma and PPARdelta. At 15 µM, FH535 blocks the recruitment of beta-catenin and GRIP1 to PPARgamma and PPARdelta. Presumably through these actions, FH535 is selectively toxic to some carcinoma cell lines expressing the Wnt/beta-catenin pathway. FH535 is used to study the role of Wnt/beta-catenin pathway in various cancer cell lines.Formal Name: 2,5-dichloro-N-(2-methyl-4-nitrophenyl)-benzenesulfonamide. CAS Number: 108409-83-2. Molecular Formula: C13H10Cl2N2O4S. Formula Weight: 361.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10 mg/ml. lambdamax: 292 nm. SMILES: ClC1=C(S(NC2=C(C)C=C([N+]([O-])=O)C=C2)(=O)=O)C=C(Cl)C=C1. InChi Code: InChI=1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3. InChi Key: AXNUEXXEQGQWPA-UHFFFAOYSA-N.
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