(±)-EX-527
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
EX-527 is an inhibitor of sirtuin 1 (SIRT1, IC50 = 0.098 µM). It is selective for SIRT1 over... more
Product information "(±)-EX-527"
EX-527 is an inhibitor of sirtuin 1 (SIRT1, IC50 = 0.098 µM). It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM. EX-527 (50 µM) induces cell cycle arrest at the G1 phase in MCF-7 cells.Formal Name: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide. CAS Number: 49843-98-3. Molecular Formula: C13H13ClN2O. Formula Weight: 248.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 233, 291 nm. SMILES: ClC(C=C1)=CC2=C1NC3=C2CCCC3C(N)=O. InChi Code: InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17). InChi Key: FUZYTVDVLBBXDL-UHFFFAOYSA-N.
| Keywords: | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 10009798 |
Properties
| Application: | SIRT1 inhibitor |
| MW: | 248.7 D |
| Formula: | C13H13ClN2O |
| Purity: | >98% |
| Format: | Crystalline Solid |
Database Information
| CAS : | 49843-98-3| Matching products |
| KEGG ID : | K11411 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301, H319 |
| P Phrases: | P264, P270, P280, P321, P330, P301+P310, P305+P351+P338, P337+P313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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