EX-229

EX-229 is an activator of AMP-activated protein kinase (AMPK). It activates AMPK and increases glucose uptake in isolated rat epitrochlearis muscle when used at a concentration of 100 µM. EX-229 also increases AMPK activation and glucose uptake in primary skeletal muscle cultures isolated from patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).Formal Name: 5-[[6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yl]oxy]-2-methyl-benzoic acid. CAS Number: 1219739-36-2. Synonyms: AMPK Activator 991. Molecular Formula: C24H18ClN3O3. Formula Weight: 431.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.30 mg/ml. lambdamax: 219, 235, 292 nm. SMILES: O=C(C1=CC(OC2=NC3=CC(Cl)=C(C4=CC(C=CN5C)=C5C=C4)C=C3N2)=CC=C1C)O. InChi Code: InChI=1S/C24H18ClN3O3/c1-13-3-5-16(10-17(13)23(29)30)31-24-26-20-11-18(19(25)12-21(20)27-24)14-4-6-22-15(9-14)7-8-28(22)2/h3-12H,1-2H3,(H,26,27)(H,29,30). InChi Key: FHWSAZXFPUMKFL-UHFFFAOYSA-N.