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Eupatilin is a flavonoid that has been found in Artemisia and has diverse biological activities. It inhibits cell growth in A375 melanoma cells when used at concentrations ranging from 25 to 800 µM. Eupatilin binds to peroxisome proliferator-activated receptor alpha (PPARalpha, IC50 = 1.18 µM) and induces reporter gene expression in CV-1 cells expressing human PPARalpha, but not PPARgamma, when used at concentrations ranging from 10 to 300 µM. It prevents hydrogen peroxide-induced disruption of the F-actin cytoskeleton and inhibition of cell migration in AGS gastric epithelial cells. Eupatilin also inhibits 5-lipoxygenase (5-LO) activity in cultured mastocytoma cells (IC50 = 14 µM). In vivo, eupatilin (5, 10, and 15 mg/kg) reduces pulmonary edema and levels of the lung injury markers surfactant protein A (SPA) and SPD in a rat model of LPS-induced acute lung injury. It reduces serum levels of histamine and increases survival in a mouse model of allergic anaphylactic shock induced by compound 48/80 (Cay-22173).Formal Name: 2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one. CAS Number: 22368-21-4. Synonyms: NSC 122413. Molecular Formula: C18H16O7. Formula Weight: 344.3. Purity: >98%. Formulation: (Request formulation change), A powder. Solubility: DMF: 50 mg/mL, DMSO: 33 mg/mL. lambdamax: 214, 242, 274, 337 nm. SMILES: O=C1C2=C(O)C(OC)=C(O)C=C2OC(C3=CC=C(OC)C(OC)=C3)=C1. InChi Code: InChI=1S/C18H16O7/c1-22-12-5-4-9(6-14(12)23-2)13-7-10(19)16-15(25-13)8-11(20)18(24-3)17(16)21/h4-8,20-21H,1-3H3. InChi Key: DRRWBCNQOKKKOL-UHFFFAOYSA-N.
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