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B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate... more
Product information "Encorafenib"
B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. A mutation of B-Raf in exon 15 at codon 600 where a valine is substituted by glutamic acid (V600E) has been linked to melanoma. Encorafenib is a selective inhibitor of B-RafV600E mutant melanoma cell proliferation (EC50 = 4 nM) with little activity against wild-type B-Raf or a panel of 100 other kinases (IC50s = 900 nM). At oral doses of 6 mg/kg in human melanoma xenograft models, encorafenib was shown to decrease phosphorylation of the B-Raf substrate MEK.Formal Name: N-[(1S)-2-[[4-[3-[5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-carbamic acid, methyl ester. CAS Number: 1269440-17-6. Synonyms: LGX818. Molecular Formula: C22H27ClFN7O4S. Formula Weight: 540.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 15 mg/ml. SMILES: O=C(OC)N[C@@H](C)CNC1=NC(C2=CN(C(C)C)N=C2C3=CC(Cl)=CC(NS(C)(=O)=O)=C3F)=CC=N1. InChi Code: InChI=1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1. InChi Key: CMJCXYNUCSMDBY-ZDUSSCGKSA-N.
Keywords: | LGX818, N-[(1S)-2-[[4-[3-[5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-carbamic acid, methyl ester |
Supplier: | Cayman Chemical |
Supplier-Nr: | 16994 |
Properties
Application: | B-Raf V600E mutant inhibitor |
MW: | 540 D |
Formula: | C22H27ClFN7O4S |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 1269440-17-6| Matching products |
KEGG ID : | K04365 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H302, H315, H319, H335, H351, H361, H372 |
P Phrases: | P201, P202, P260, P261, P264, P270, P271, P280, P312, P314, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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