215 products were found matching "K04365"!

Formulation: Purified Ab with BSA and Azide at 200ug/ml. Cellular Localization: Nucleus. Cytoplasm. Cell membrane. Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. Positive Control: A431, Jurkat or HeLa cells. Human melanoma or colon carcinoma. Chromosome Location: 7q34. Protein Function: Protein...

Formulation: Purified Ab with BSA and Azide at 200ug/ml. Cellular Localization: Cytoplasm. Positive Control: A431, Jurkat or HeLa cells. Human melanoma, brain, testis or colon carcinoma. Chromosome Location: 7q34. Protein Function: Protein kinase involved in the transduction of mitogenic signals from the cell...

Formulation: Purified Ab WITHOUT BSA and Azide at 1.0mg/ml. Cellular Localization: Cytoplasm. Positive Control: A431, Jurkat or HeLa cells. Human melanoma, brain, testis or colon carcinoma. Chromosome Location: 7q34. Protein Function: Protein kinase involved in the transduction of mitogenic signals from the cell...

Formulation: Purified Ab with BSA and Azide at 200ug/ml. Cellular Localization: Cytoplasm. Positive Control: A431, Jurkat and HeLa cells. Human melanoma and colon carcinoma, Human Skeletal Muscles. Chromosome Location: 7q34. Protein Function: Protein kinase involved in the transduction of mitogenic signals from the...

Formulation: Purified Ab WITHOUT BSA at 1.0mg/ml. Cellular Localization: Cytoplasm. Positive Control: A431, Jurkat and HeLa cells. Human melanoma and colon carcinoma, Human Skeletal Muscles. Chromosome Location: 7q34. Protein Function: Protein kinase involved in the transduction of mitogenic signals from the cell...

Formulation: Purified Ab WITHOUT BSA at 1.0mg/ml. Cellular Localization: Nucleus. Cytoplasm. Cell membrane. Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. Positive Control: A431, Jurkat or HeLa cells. Human melanoma or colon carcinoma. Chromosome Location: 7q34. Protein Function: Protein kinase...

Concentration: 0.5 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. B-Raf is a member of the Raf family of Ser/Thr protein kinases. It functions downstream of Ras to regulate the MAP kinase signaling pathway. Mutations in the BRAF gene cause diseases. Inherited mutations in...

CFT-1946 is a degrader of the mutant B-RAF isoforms B-RAFV600E, B-RAFG469A, and B-RAFG466V. InChI:...

PLX4032 is an orally bioavailable, ATP-competitive inhibitor of mutant V600E and wild type B-Raf kinases (IC50s = 31 and 100 nM, respectively). It inhibits cell proliferation in a variety of cell lines expressing B-Raf V600E and synergizes strongly with taxol, vinblastine, and oxaliplatin in inhibiting the...

Human v-raf murine sarcoma viral oncogene homolog B1 (BRAF), GenBank Accession No. NM_004333, a.a. 417-end with Val-to-Glu mutation on a.a. 600 and N-terminal GST tag, MW=69 kDa, expressed in Sf9 insect cells via a baculovirus expression system. This mutation is often cited as V599E.

The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-RafV600E occurs in melanomas and thyroid cancer but is poorly targeted by many inhibitors of...

B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. A mutation of B-Raf in exon 15 at codon 600 where a valine is substituted by glutamic acid (V600E) has been linked to melanoma. Encorafenib is a selective inhibitor of B-RafV600E mutant...