Emtricitabine

Emtricitabine is a nucleoside analog and an inhibitor of HIV-1 and hepatitis B reverse transcriptase with antiviral activity. It inhibits replication of HIV-1 (EC50s = 10-20 nM) and hepatitis B (EC50s = 10-40 nM) in various cell lines. Emtricitabine inhibits duck hepatitis B viral DNA synthesis when administered pre- and post-viral inoculation in primary duck hepatocytes. In vivo, emtricitabine (3-30 mg/kg) reduces viremia and hepatic woodchuck hepatitis virus (WHV) replication in a dose-dependent manner in a woodchuck model of chronic WHV infection. Formulations containing emtricitabine have been used in the treatment of HIV infection.Formal Name: 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone. CAS Number: 143491-57-0. Synonyms: BW 1592, BW 524W91, FTC. Molecular Formula: C8H10FN3O3S. Formula Weight: 247.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 238, 283 nm. SMILES: O=C1N([C@H]2O[C@@H](CO)SC2)C=C(F)C(N)=N1. InChi Code: InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m0/s1. InChi Key: XQSPYNMVSIKCOC-NTSWFWBYSA-N.