ELR510444

ELR510444 is an inhibitor of tubulin polymerization (IC50 = 10 µM) that binds to tubulin at the colchicine (Cay-9000760) binding site. It induces microtubule depolymerization in A-10 cells (EC50 = 21 nM). ELR510444 inhibits growth in a cancer cell line panel (IC50s = 9-43 nM) via formation of multiple spindles and induction of mitotic arrest. Oral administration of ELR510444 (3-6 mg/kg) reduces tumor size in an MDA-MB-231 breast cancer mouse xenograft model in a dose-dependent manner. ELR510444 also inhibits hypoxia-inducible factor 1alpha (HIF-1alpha) in RCC4 cells in a concentration-dependent manner.Formal Name: N-[5-(5-cyano-2-thienyl)-2-methylphenyl]-4-methyl-benzenesulfonamide. CAS Number: 1233948-35-0. Molecular Formula: C19H16N2O2S2. Formula Weight: 368.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Methyl Acetate: 10 mg/ml. lambdamax: 309 nm. SMILES: CC1=CC=C(S(NC2=C(C)C=CC(C3=CC=C(C#N)S3)=C2)(=O)=O)C=C1. InChi Code: InChI=1S/C19H16N2O2S2/c1-13-3-8-17(9-4-13)25(22,23)21-18-11-15(6-5-14(18)2)19-10-7-16(12-20)24-19/h3-11,21H,1-2H3. InChi Key: GRYXROIHHXHFND-UHFFFAOYSA-N.