(E/Z)-4-hydroxy Tamoxifen

(E/Z)-4-hydroxy Tamoxifen
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay17308-5 5 mg -

6 - 10 business days*

43.00€
Cay17308-10 10 mg -

6 - 10 business days*

82.00€
Cay17308-25 25 mg -

6 - 10 business days*

176.00€
Cay17308-50 50 mg -

6 - 10 business days*

308.00€
 
(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Cay-13258). It is formed from... more
Product information "(E/Z)-4-hydroxy Tamoxifen"
(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Cay-13258). It is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (E/Z)-4-hydroxy Tamoxifen is cytotoxic to MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively). It also stimulates LC3 lipidation and the formation of autophagic vesicles in MCF-7 cells in a superoxide-dependent manner.Formal Name: 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol. CAS Number: 68392-35-8. Synonyms: Afimoxifene, 4-OHT. Molecular Formula: C26H29NO2. Formula Weight: 387.5. Purity: >98% (mixture of isomers). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 2 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 246, 287 nm. SMILES: CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(OCCN(C)C)C=C3. InChi Code: InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-. InChi Key: TXUZVZSFRXZGTL-QPLCGJKRSA-N.
Keywords: 4-hydroxy Tamoxifen, 4-OHT, Afimoxifene, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol
Supplier: Cayman Chemical
Supplier-Nr: 17308

Properties

Application: Active tamoxifen metabolite, estrogen receptor agonist/antagonist
MW: 387.5 D
Formula: C26H29NO2
Purity: >98% (E) and (Z) isomers (50:50)
Format: Crystalline Solid

Database Information

CAS : 68392-35-8| Matching products
KEGG ID : K08550 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H312, H315, H319, H332, H335, H361
P Phrases: P201, P202, P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P308+313, P312, P321, P330, P332+313, P337+313, P361+364, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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