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DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2. When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the inhibition of COX-2 than COX-1. The IC50 values for human recombinant COX-2 are 80 and 40 nM at 5 and 10 minutes, respectively. The IC50 for the inhibition of human recombinant COX-1 after the same time intervals is 9 µM. DuP-697 also attenuates the COX-1 inhibitory activity of non-selective COX inhibitors such as indomethacin.Formal Name: 5-bromo-2-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-thiophene. CAS Number: 88149-94-4. Molecular Formula: C17H12BrFO2S2. Formula Weight: 411.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 54 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 15 mg/ml, Ethanol: 7 mg/ml. lambdamax: 254, 300 nm. SMILES: Fc1ccc(cc1)c1sc(Br)cc1c1ccc(cc1)S(=O)(=O)C. InChi Code: InChI=1S/C17H12BrFO2S2/c1-23(20,21)14-8-4-11(5-9-14)15-10-16(18)22-17(15)12-2-6-13(19)7-3-12/h2-10H,1H3. InChi Key: AJFTZWGGHJXZOB-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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