These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Conversion and usertracking via Google Tag Manager
DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 µM), Cdk7 (IC50 = ~20 µM), Cdk8 (IC50 = ~20 µM), and Cdk9 (IC50 = 3 µM). Through inhibition of certain CTD kinases, DRB inhibits an elongation step during RNA polymerase II transcription, which can trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells. DRB can also inhibit HIV transcription (IC50 = ~4 µM) by targeting elongation enhanced by the HIV-encoded transactivator Tat. Formal Name: 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole. CAS Number: 53-85-0. Synonyms: Benzimidazole, NSC 401575. Molecular Formula: C12H12Cl2N2O4. Formula Weight: 319.1. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 214 nm. SMILES: O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C=NC3=C2C=C(Cl)C(Cl)=C3. InChi Code: InChI=1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1. InChi Key: XHSQDZXAVJRBMX-DDHJBXDOSA-N.