Donepezil

Donepezil is an inhibitor of acetylcholinesterase (AChE, IC50 = 6.7 nM). It is selective for AChE over butyrylcholinesterase (BChE, IC50 = 988 nM). Donepezil (0.1 and 1 µM) inhibits the production of nitric oxide (NO) and TNF-alpha induced by oligomeric amyloid-beta (1-42) (AbetaO1-42) in primary rat microglial cells. It increases ACh levels in the cortex and hippocampus of aged rats when administered at a dose of 1.5 mg/kg. Donepezil (2 mg/kg) reduces Mac-1 and GFAP protein expression, markers of microglia and astrocyte activation, respectively, in the hippocampal dentate gyrus of a mouse model of Alzheimer's disease induced by intrahippocampal injection of AbetaO1-42. It increases step-through latency in a passive avoidance test in the same model. Formulations containing donepezil have been used in the treatment of Alzheimer's disease.Formal Name: 2,3-dihydro-5,6-dimethoxy-2[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one. CAS Number: 120014-06-4. Molecular Formula: C24H29NO3. Formula Weight: 379.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Acetone: 25 mg/ml, Chloroform: 50 mg/ml. lambdamax: 208, 231, 269, 314 nm. SMILES: O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41. InChi Code: InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3. InChi Key: ADEBPBSSDYVVLD-UHFFFAOYSA-N.