Dofetilide-d4

Dofetilide-d4 is intended for use as an internal standard for the quantification of dofetilide (Cay-15045) by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes). However, at 1 µM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg. Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.Formal Name: N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl-1,1,2,2-d4]amino]ethyl]phenyl]-methanesulfonamide. CAS Number: 1189700-56-8. Molecular Formula: C19H23D4N3O5S2. Formula Weight: 445.6. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Methanol: slightly soluble. SMILES: CS(NC1=CC=C(OC([2H])([2H])C([2H])([2H])N(C)CCC2=CC=C(NS(C)(=O)=O)C=C2)C=C1)(=O)=O. InChi Code: InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3/i14D2,15D2. InChi Key: IXTMWRCNAAVVAI-QZPARXMSSA-N. Origin: Synthetic.